START WITH WHAT YOU MAY NOTICE
Sermorelin: What Might You Notice?
Sleep and waist size may bring you here. See how the IGF-1 growth blood test changed, and what studies haven't shown.
Promise Peptides prescribes sermorelin today.
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What can Sermorelin studies answer?
Trouble sleeping may grab your attention first. A thicker waist may worry you too. Sermorelin hasn't been proved to fix either one. It copies 29 protein building blocks from a brain hormone.
Those blocks form part of a short chain. The brain hormone asks your growth gland to work. Sermorelin carries the same request. It isn't growth hormone from a vial.
The early studies followed slow-growing children. Later work followed older men for two weeks. Doctors measured growth hormone and IGF-1, a growth substance in blood.
The clearest results came from those two groups. A related drug gave the best fat result. That drug wasn't sermorelin.
You'll find personal accounts on the effects page. Those accounts aren't the same as study proof. You won't have to guess which kind you're reading.
How does Sermorelin change growth hormones?
The growth gland rests at your brain's base. Sermorelin reaches growth-making cells there [1]. Those cells send growth hormone out. IGF-1, a growth substance in blood, then rises; the amounts rise and fall through the day.
Two body hormones can slow the gland [6]. One starts in your brain. IGF-1 can send a stop message too. These are your body's usual checks on growth hormone; they help keep the amount from staying high.
Children with too little growth hormone got daily shots. During year one, growth climbed from about 4.1 cm/year toward 7-8 cm/year [2]. Their IGF-1 level didn't climb too high. That finding applies to those children.
Healthy men around 68 years old were also studied. They used sermorelin twice daily for two weeks. Their growth hormone and IGF-1 rose during 24-hour checks.
At the higher amount, both matched young men's levels [3]. The IGF-1 change can't predict your result. You can ask what those blood changes mean for you.
Whose body fat went down?
When you haven't eaten, growth hormone helps tap stored fat [11]. Researchers tested tesamorelin, a related drug, in older adults. After 20 weeks, their body fat was about 7.4% lower.
Their IGF-1 growth blood test rose 117% but stayed normal [7]. Another fair test found body changes in adults with obesity [8]. Those people weren't healthy adults taking sermorelin.
No fair test has proved fat loss from sermorelin in healthy adults [10]. Its use for fat loss or aging isn't approved. The related drug gives researchers a reason to keep looking. It can't tell you what your waist or weight will do.
Your health and habits also matter. Read sermorelin weight loss for the drug names. Then see the study times at sermorelin before and after. You won't get a weight promise from those findings.
When might a doctor discuss Sermorelin?
FDA once cleared Sermorelin as a shot. Doctors used it for children with low growth hormone. The drug left the U.S. market in 2008. The company made a business choice; no new harm caused it [6].
A clinician licensed to care for a U.S. patient must decide whether to prescribe injectable sermorelin before a pharmacy prepares it. The policy calls it Category 1, which means federal review isn't finished. The government may hold off on action when the pharmacy follows set rules.
The latest guide came in January 2025. This label isn't approval or proof of safety. Your doctor can explain what it means for your care.
Sermorelin isn't approved for aging, fat loss, or muscle gain. One doctor review found too little proof for aging [5]. These pages can't give you personal care.
Read Sermorelin research for the studies. Check Sermorelin effects for reports and risks. The papers are under Sermorelin references. You'll need a licensed doctor for your own questions.